1.團(tuán)隊(duì)負(fù)責(zé)人：
2.團(tuán)隊(duì)成員：
3.研究方向：
方向一：益生菌益生性質(zhì)、益生機(jī)理及其調(diào)控機(jī)制
研究內(nèi)容：開展自然發(fā)酵乳的微生物生態(tài)和功能菌種的發(fā)酵機(jī)制，開發(fā)功能性發(fā)酵乳的工業(yè)化生產(chǎn)技術(shù)；發(fā)酵法制備生物活性肽，在分子、細(xì)胞和動(dòng)物水平研究其生物活性的生物學(xué)機(jī)制。
方向二：微生物環(huán)境適應(yīng)性機(jī)制及其酶的開發(fā)應(yīng)用
研究內(nèi)容：利用多組學(xué)、反向遺傳學(xué)、生物化學(xué)等多學(xué)科技術(shù)手段研究不同環(huán)境脅迫下紅酵母中油脂、多不飽和脂肪酸、類胡蘿卜素、胞外多糖等多種天然生物活性物質(zhì)合成與環(huán)境脅迫適應(yīng)性之間的關(guān)系，揭示不同環(huán)境脅迫條件下這些生物活性物質(zhì)合成調(diào)節(jié)的信號轉(zhuǎn)導(dǎo)途徑及其調(diào)節(jié)機(jī)制，進(jìn)一步結(jié)合代謝網(wǎng)絡(luò)模型構(gòu)建和代謝工程策略構(gòu)建高效生產(chǎn)不同生物活性物質(zhì)的代謝工程菌株。
方向三：人體微生物組
研究內(nèi)容：聚焦微生物組在女性生殖健康（不孕癥、HPV感染）及癌癥（甲狀腺癌、宮頸癌、結(jié)直腸癌）中的作用機(jī)制，探究分娩方式（自然分娩/剖腹產(chǎn)）對新生兒腸道菌群定植及早期健康的影響，為疾病防治和母嬰健康提供新策略。
方向四：功能性發(fā)酵食品研發(fā)及其活性機(jī)制的研究
研究內(nèi)容：開發(fā)具備降尿酸、降血壓作用的發(fā)酵乳制品，調(diào)節(jié)睡眠的益生菌豆?jié){豆豉和益生性鋒產(chǎn)品，以及探究功能食品發(fā)揮益生效用的分子機(jī)制。
4.團(tuán)隊(duì)成果：
（1）承擔(dān)項(xiàng)目
近5年主持國家自然科學(xué)基5項(xiàng)，省部級基金10項(xiàng)。
國家基金地區(qū)項(xiàng)目，32460229，不同CUPP分類來源S8角蛋白酶的底物特異性及其機(jī)制研究，2025/01-2028/12，在研，國家級
國家基金地區(qū)項(xiàng)目，32360566，熱脅迫下麥芽糖促進(jìn)粘紅酵母胞外多糖合成的分子調(diào)控機(jī)制研究，2024/01-2027/12，在研，國家級
國家基金地區(qū)項(xiàng)目，32260579，植物乳桿菌中pABA生物合成相關(guān)基因的發(fā)掘及對葉酸生物合成的分子調(diào)控機(jī)理初探，2023/01-2026/12，在研，國家級
國家基金地區(qū)項(xiàng)目，32260249，白腐菌HSF調(diào)控木質(zhì)纖維素降解酶的合成機(jī)制及轉(zhuǎn)化性能分析，2023/01-2026/12，在研，國家級
國家基金地區(qū)項(xiàng)目，32260863，腸道菌介導(dǎo)調(diào)節(jié)蜂王性成熟的分子機(jī)制研究，2023/01-2026/12，在研，國家級
云南省“興滇英才支持計(jì)劃”青年人才項(xiàng)目，KKXX202426053，基于酶的挖掘改造及構(gòu)效機(jī)制開發(fā)云南特色植物微生物蛋白，2024/01-2028/12，在研，省部級
科技廳面上項(xiàng)目，202401CF070142，人體尿道生殖道古菌菌群的研究，，2024/03-2027/02，在研，省部級
科技廳面上項(xiàng)目，202401AT070390，嗜熱角蛋白降解菌耐受還原劑的適應(yīng)性進(jìn)化及其機(jī)制解析，2024/03-2027/02，在研，省部級
科技廳昆明理工大學(xué)“雙一流”創(chuàng)建聯(lián)合專項(xiàng)面上項(xiàng)目，202201BE070001-024，202201BE070001/024，嗜熱微生物高效降解角蛋白的機(jī)理及應(yīng)用研究，2022/10-2025/09，在研，省部級
云南省鄉(xiāng)村振興科技專項(xiàng)科技特派員項(xiàng)目，云財(cái)教〔2022〕167號，云南省鄉(xiāng)村振興科技特派員-郭軍，2022/01-2024/12，在研，省部級
云南省三區(qū)人才項(xiàng)目，云財(cái)教【2022】158號，2022年度云南省三區(qū)人才-郭軍，2022/06-2023/05，在研，省部級
科技廳面上項(xiàng)目，202201AT070191無菌蜂王模型的構(gòu)建及功能評價(jià)，郭軍，2022/06-2025/05，在研，省部級
云南省三區(qū)人才項(xiàng)目，國科農(nóng)函〔2021〕25號，2021年云南省“三區(qū)”科技人才-郭軍，2021/08-2022/08，在研，省部級
科技廳面上項(xiàng)目，202101AT070139，植物乳桿菌在德昂族自然發(fā)酵酸茶中的抗氧化機(jī)制研究，2021/04-2024/03，驗(yàn)收，省部級
科技廳面上項(xiàng)目，202101AT070070，Lactobacillus plantarum RB/4菌株對展青霉素降解的機(jī)制研究，2021/04-2024/03，驗(yàn)收，省部級
（2）發(fā)表論文專著
近5年發(fā)表SCI論文60余篇。
1. Li JL, Li WL, Zhang J, Pang YT, Xiong J, Wu P, Wei BR, Li XJ, Huang Q, Tang QH, Zhao CH, Wang Q, Liu ZL, Chen Y, Dong ZX, Zhao YZ, Guo J. Seasonal dynamics of the microbiota and nutritional composition in bee bread from Apis cerana and Apis mellifera colonies. Food Res Int. 2024 8;190:113905.
2. Zhao SH, Zhang SM, Yang JW, Liu CJ, Zeng XQ, Zhang YL, Chen SQ, Zhao ZM, Xia YX, Li XR, Shang Y. Preliminary study on the active substances and cellular pathways of lactic acid bacteria for colorectal cancer treatment. J Cancer. 2024 7 16;15(15):4902-4921.
3. Wang T, Xiong YG, Si TZ, Yan JP, Li XR, Liu CJ, Yang E. Effects of priming glycosyltransferase genes cps 2E and cps 4E on the exopolysaccharide biosynthesis byLactiplantibacillus plantarumYM-4-3 strain. Int J Biol Macromol. 2024 6;269(Pt 1):131813.
4. Huang X, Fan J, Guo C, Chen Y, Qiu J, Zhang Q. Integrated Transcriptomics and Metabolomics Analysis Reveal the Regulatory Mechanisms Underlying Sodium Butyrate-Induced Carotenoid Biosynthesis in Rhodotorula glutinis. J Fungi (Basel). 2024 4; 27;10(5):320.
5. Dong YH, Luo YH, Liu CJ, Huang WY, Feng L, Zou XY, Zhou JY, Li XR. Changes in microbial composition and interaction patterns of female urogenital tract and rectum in response to HPV infection. J Transl Med. 2024 2 1;22(1):125.
6. Zhang S, Hu X, Zhang C, Ju Y, Liu X, Wei Y. Dopamine alters phage morphology to exert an anti-infection effect. Front Microbiol. 2023 11 9;14:1272447.
7. Tang Q, Li W, Wang Z, Dong Z, Li X, Li J, Huang Q, Cao Z, Gong W, Zhao Y, Wang M, Guo J. Gut microbiome helps honeybee (Apis mellifera) resist the stress of toxic nectar plant (Bidens pilosa) exposure: Evidence for survival and immunity. Environ Microbiol. 2023 10;25(10):2020-2031.
8. Li WL, Huang Q, Li JL, Wu P, Wei B, Li XJ, Tang QH, Dong ZX, Xiong J, Tang H, Zhang J, Zhao CH, Cao Z, Chen Y, Zhao WZ, Wang K, Guo J. Gut microbiota-driven regulation of queen bee ovarian metabolism. Microbiol Spectr. 2023 9 26;11(5):e0214523.
9. Zou H, Ding Y, Shang J, Ma C, Li J, Yang Y, Cui X, Zhang J, Ji G, Wei Y. Isolation, characterization, and genomic analysis of a novel bacteriophage MA9V-1 infectingChryseobacterium indologenes: a pathogen of Panax notoginseng root rot. Front Microbiol. 2023 9 14;14:1251211.
10. Zhang S, Shi C, Liu C, Zou X, Gong F, Li X. Dynamic Analysis of the Bacterial Community and Determination of Antioxidant Capacity during the Fermentation of Sour Tea. Fermentation. 2023; 9(2):161.
11. He M, Guo R, Chen G, Xiong C, Yang X, Wei Y, Chen Y, Qiu J, Zhang Q. Comprehensive Response ofRhodosporidium kratochvilovaeto Glucose Starvation: A Transcriptomics-Based Analysis. Microorganisms. 2023 8 27;11(9):2168.
12. Feng Y, Zeng S, Yan J, Li K, Xu H. Genome-Wide Analysis and Expression of MYC Family Genes in Tomato and the Functional Identification of slmyc1 in Response to Salt and Drought Stress. Agronomy. 2023; 13(3):757.
13. Zou, L., Su, J., Xu, T., Ji, X., Wang, T., Chen, Y., Jiang, Y., Qiu, J., Zhang, Q. & Hu, B. Untargeted metabolomics revealing changes in aroma substances in flue-cured tobacco. Open Chemistry, 2023 4;21(1), 20220326.
14. Li Y, Xiong L, Yu H, Xiang Y, Wei Y, Zhang Q, Ji X. Biogeochemical sulfur cycling of virus auxiliary metabolic genes involved in Napahai plateau wetland. Environ Sci Pollut Res Int. 2023 3;30(15):44430-44438.
15. Xie L, Cheng L, Wei Y. Mitomycin C enhanced the antitumor efficacy of Rocaglamide in colorectal cancer. Pathol Res Pract. 2023 3;243:154350.
16. Zhai J, Liang Y, Zeng S, Yan J, Li K, Xu H. Overexpression of tomato glutathione reductase (SlGR) in transgenic tobacco enhances salt tolerance involving the S-nitrosylation of GR. Plant Physiol Biochem. 2023 3;196:497-506.
17. Gao H, Feng GD, Feng Z, Yao Q, Li J, Deng X, Li X, Zhu H. Pseudomonas citri sp. nov., a potential novel plant growth promoting bacterium isolated from rhizosphere soil of citrus. Antonie Van Leeuwenhoek. 2023 3;116(3):281-289.
18. Dong YH, Fu Z, Zhang NN, Shao JY, Shen J, Yang E, Sun SY, Zhao ZM, Xiao A, Liu CJ, Li XR. Urogenital tract and rectal microbiota composition and its influence on reproductive outcomes in infertile patients. Front Microbiol. 2023 2,10;14:1051437.
19. Tang QH, Li WL, Wang JP, Li XJ, Li D, Cao Z, Huang Q, Li JL, Zhang J, Wang ZW, Guo J, Li JL. Effects of spinetoram and glyphosate on physiological biomarkers and gut microbes inBombus terrestris. Front Physiol. 2023 1, 9;13:1054742.
20. Dong, Y., Zhai, J., Yan, J., Li, K., & Xu, H. Physiological and transcriptomic responses of antioxidant system and nitrogen metabolism in tomato seedlings treated with nitrogen starvation and re-supply. The Journal of Horticultural Science and Biotechnology, 2022; 98(1), 57–71.
21. Guo R, Liu T, Guo C, Chen G, Fan J, Zhang Q. Carotenoid biosynthesis is associated with low-temperature adaptation in Rhodosporidium kratochvilovae. BMC Microbiol. 2022 12, 24;22(1):319.
22. Wu YR, Dong YH, Liu CJ, Tang XD, Zhang NN, Shen J, Wu Z, Li XR, Shao JY. Microbiological composition of follicular fluid in patients undergoing IVF and its association with infertility. Am J Reprod Immunol. 2023 3;89(3):e13652.
23. Zhu G, Tan W, Xie L, Ma C, Chen X, Zhang S, Wei Y. Mechanisms underlying the inhibitory effects of Cd2+ on prodigiosin synthesis in Serratia marcescens KMR-3. J Inorg Biochem. 2022 11;236:111978.
24. Qiao S , Feng Y , Yan J , Li H, Xu H. Overexpression of tomato SlTpx improves salt stress tolerance in transgenic tobacco plants by scavenging H2O2.Plant Cell, Tissue and Organ Culture (PCTOC), 2022, 151(2):321-333.
25. Zhu G, Xie L, Tan W, Ma C, Wei Y. Cd2+ tolerance and removal mechanisms of Serratia marcescens KMR-3. J Biotechnol. 2022 11, 20;359:65-74.
26. He M, Yang X, Liu T, Zhang X, Ji X, Wei Y, Zhang Q. Hybrid histidine kinase HisK2301 modulates carotenoid production to counteract cold-induced oxidative stress in Rhodosporidium kratochvilovae YM25235 under low temperature. Antonie Van Leeuwenhoek. 2022 12;115(12):1393-1404.
27. Dong ZX, Tang QH, Li WL, Wang ZW, Li XJ, Fu CM, Li D, Qian K, Tian WL, Guo J. Honeybee (Apis mellifera) resistance to deltamethrin exposure by Modulating the gut microbiota and improving immunity. Environ Pollut. 2022 12, 1;314:120340.
28. Cai S B , Wu G , Dong Z X , Lin L B, Guo J, Zhang Q L.Colonization dynamics of the gut flora in western honey bee workers within 7-day post-emergence.Apidologie, 2022 8;53, 44.
29.于航,徐志偉,魏云林,等.病毒輔助代謝基因的研究進(jìn)展.微生物學(xué)報(bào), 2022, 62(8):2879-2892.
30. Liu CJ, Xiao WY, Fang JF, Dong YH, Ye KF, He MP, Wang YS, Li X, Zhao ZM, Yuan T, Zhao T, He CY, Zhang SM, Yang E, Wu XM, Li XR. Genital Microbiota of Women From Six Ethnic Groups With and Without Human Papillomavirus Infection in Shangri-La, China. Front Cell Infect Microbiol. 2022 2, 8;12:935068.
31. Chen W, Zhang X, Li S, Cui J, Yang X, Zhang Q. The MAP-Kinase HOG1 Controls Cold Adaptation in Rhodosporidium kratochvilovae by Promoting Biosynthesis of Polyunsaturated Fatty Acids and Glycerol. Curr Microbiol. 2022 7, 14;79(9):253.
32. Qu Y, Luo Y, Yang X, Zhang Y, Yang E, Xu H, He Y, Chagan I, Yan J. Highly Efficient Biotransformation of Phenolic Glycosides Using a Recombinant β-Glucosidase From White Rot Fungus Trametes trogii. Front Microbiol. 2022 5, 18;13:762502.
33. Shan Y, Shang J, Zhang D, Cui Y, Wang Y, Zhu J, Ma Y, Song P, Qin K, Ji X, Wei Y, Wu L .Cloning, Expression and Biochemical Characterization of the Recombinant α-amylase from Bacillus subtilis YX48.Current Proteomics, 2022 2;19(3)218:225.
34. Zhai J, Qi Q, Wang M, Yan J, Li K, Xu H. Overexpression of tomato thioredoxin h (SlTrxh) enhances excess nitrate stress tolerance in transgenic tobacco interacting with SlPrx protein. Plant Sci. 2022 2;315:111137.
35. Xiang Y, Ma C, Yin S, Song F, Qin K, Ding Y, Yang X, Song P, Ji X, Wei Y. Phage therapy for refractory periapical periodontitis caused by Enterococcus faecalis in vitro and in vivo. Appl Microbiol Biotechnol. 2022 3;106(5-6):2121-2131.
36. Xie L, Ji X, Zhang Q, Wei Y. Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer. Biomed Pharmacother. 2022 2;146:112567.
37. Gao J, Liu N, Zhang X, Yang E, Song Y, Zhang J, Han Q. Utilizing the DNA Aptamer to Determine Lethal α-Amanitin in Mushroom Samples and Urine by Magnetic Bead-ELISA (MELISA). Molecules. 2022 1, 15;27(2):538.
38. Zhang C, Zheng , Bai , Luo Q, Shang , Xie L , Wei Y . Novel Carbon Dots Based on Pseudomonas aeruginosa for High Selectivity Detection of Cr6+ and Bioimaging Both in vitro and in vivo. Nano, 2022;17 (01).
39.Ding Y, Zhang D, Zhao X, Tan W, Zheng X, Zhang Q, Ji X, Wei Y. Autoinducer-2-mediated quorum-sensing system resists T4 phage infection in Escherichia coli. J Basic Microbiol. 2021 12;61(12):1113-1123.
40. Xie L, Zhu G, Shang J, Chen X, Zhang C, Ji X, Zhang Q, Wei Y. An overview on the biological activity and anti-cancer mechanism of lovastatin. Cell Signal. 2021 11;87:110122.
41. Zhang C, Qin K, Zheng X, Luo Q, Zhang Q, Ji X, Wei Y. Synthesis of carbon dots with antiphage activity using caffeic acid. Anal Methods. 2021 11, 11;13(43):5165-5172.
42. Liu CJ, Chen SQ, Zhang SY, Wang JL, Tang XD, Yang KX, Li XR. The comparison of microbial communities in thyroid tissues from thyroid carcinoma patients. J Microbiol. 2021 11,;59(11):988-1001.
43. Jie, W.，Ping, L.，Shengting, Z.，Wanwan, L.，Xiuling, J.，Jing, L.,et al., .A Novel GLP-1R/fHCS Method to Determine the Bioactivity of Glucagon- Like Peptide 1(GLP-1) Analogous Drugs In Vitro. Current Pharmaceutical Analysis 2021;17(9), 1197-1205
44. Tang Q , Xiong J , Wang J , Cao Z , Liao S , Xiao Y , Tian W , Guo Jun.Queen bee larva consumption improves sleep disorder and regulates gut microbiota in mice with PCPA-induced insomnia. Food Bioscience, 2021(43-):43.
45. Ba Y , Zhai J , Yan J , Li K , Xu H .H2S improves growth of tomato seedlings involving the MAPK signaling. Scientia Horticulturae, 2021, 288:110366.
46.徐志偉,陳學(xué)梅,魏云林,等.基于宏基因組分析納帕海高原濕地微生物及其碳氮代謝多樣性.生物工程學(xué)報(bào), 2021 9,37(09).
47. Guo R, He M, Zhang X, Ji X, Wei Y, Zhang QL, Zhang Q. Genome-Wide Transcriptional Changes of Rhodosporidium kratochvilovae at Low Temperature. Front Microbiol. 2021 9, 16;12:727105.
48. Zhang Y, Dong Z, Luo Y, Yang E, Xu H, Chagan I, Yan J. The Manganese Peroxidase Gene Family of Trametes trogii: Gene Identification and Expression Patterns Using Various Metal Ions under Different Culture Conditions. Microorganisms. 2021 12, 16;9(12):2595.
49. Tang QH, Miao CH, Chen YF, Dong ZX, Cao Z, Liao SQ, Wang JX, Wang ZW, Guo J. The composition of bacteria in gut and beebread of stingless bees (Apidae: Meliponini) from tropics Yunnan, China. Antonie Van Leeuwenhoek. 2021 8;114(8):1293-1305.
50. Yang E, Fan L, Jiang Y, Doucette C, Fillmore S, Han Q. Effect of natural antimicrobial agent (MicroGARD) combined with edible coating (NatureSeal) treatment on fresh-cut butternut squash. J Food Sci. 2021 5;86(5):2035-2044.
51. Liu L, Qin K, Yin S, Zheng X, Li H, Yan H, Song P, Ji X, Zhang Q, Wei Y, Zhao L. Bifunctional Carbon Dots Derived From an Anaerobic Bacterium of Porphyromonas gingivalis for Selective Detection of Fe3+ and Bioimaging. Photochem Photobiol. 2021 5;97(3):574-581.
52. Dong ZX, Chen YF, Li HY, Tang QH, Guo J. The Succession of the Gut Microbiota in Insects: A Dynamic Alteration of the Gut Microbiota During the Whole Life Cycle of Honey Bees (Apis cerana). Front Microbiol. 2021 4, 14;12:513962.
53．Zhang Y, Wu Y, Yang X, Yang E, Xu H, Chen Y, Chagan I, Yan J. Alternative Splicing of Heat Shock Transcription Factor 2 Regulates the Expression of Laccase Gene Family in Response to Copper in Trametes trogii. Appl Environ Microbiol. 2021 4, 15;87(8):e00055-21.
54. Luo Z W , Jiang Y H , Lin L B , Deng X Y, Zhang Q, Zhang Q L.Genome-wide differential expression analysis explores antibacterial molecular mechanisms of zebrafish intestine upon pathogenic Streptococcus agalactiae challenge.Aquaculture Reports, 2021, 19:100639.
55. Luo Q , Qin K , Liu F , Zheng X , Ding Y , Zhang C , Xu M , Liu X , Wei Y . Carbon dots derived from kanamycin sulfate with antibacterial activity and selectivity for Cr6+ detection. Analyst. 2021 3, 21;146(6):1965-1972.
56. Liu L, Zhang S, Zheng X, Li H, Chen Q, Qin K, Ding Y, Wei Y. Carbon dots derived from Fusobacterium nucleatum for intracellular determination of Fe3+ and bioimaging both in vitro and in vivo. Anal Methods. 2021 3, 11;13(9):1121-1131.
57. Zheng X , Qin K , He L , Ding Y , Luo Q , Zhang C , Cui X , Tan Y , Li L , Wei Y . Novel fluorescent nitrogen-doped carbon dots derived from Panax notoginseng for bioimaging and high selectivity detection of Cr6. Analyst. 2021 2, 7;146(3):911-919.
58. Ji X , Wang S , Luo Y , Yuan X , Wei Y , Zhang Q , Qin K , Tu Y.Green synthesis of weissella-derived fluorescence carbon dots for microbial staining, cell imaging and dual sensing of vitamin B12 and hexavalent chromium.Dyes and Pigments, 2021, 184:108818.
59. Ding Y , Tan W , Zheng X , Ji X , Song P , Bao L , Zhang C , Shang J , Qin K , Wei Y . Serratia marcescens-derived fluorescent carbon dots as a platform toward multi-mode bioimaging and detection of p-nitrophenol. Analyst. 2021 1, 21;146(2):683-690.
60. Guo L, Xu W, Li C, Guo Y, Yamei, Chagan I. Comparative study of physicochemical composition and microbial community of Khoormog, Chigee, and Airag, traditionally fermented dairy products from Xilin Gol in China. Food Sci Nutr. 2021 1 19;9(3):1564-1573.
61. Cui Z, Xu Z, Wei Y, Zhang Q, Qin K, Ji X. Characterization and Genome Analysis of a Novel Mu-like Phage VW-6B Isolated from the Napahai Plateau Wetland of China. Curr Microbiol. 2021 1;78(1):150-158.
62. Tu Y , Wang S , Yuan X , Xiang Y , Qin K , Wei Y , Zhang Q; ChenX , Ji X.Facile hydrothermal synthesis of nitrogen, phosphorus-doped fluorescent carbon dots for live/dead bacterial differentiation, cell imaging and two nitrophenols detection.Dyes and Pigments, 2021, 184(000).
（3）所獲知識產(chǎn)權(quán)和技術(shù)標(biāo)準(zhǔn)
近5年授權(quán)專利32項(xiàng)。
1.一種駝乳源小分子肽及其應(yīng)用，伊日布斯，王嘉鑫，嚴(yán)金平，2024/11，ZL 202310089954.3
2.無刺蜂越冬飼喂裝置和蜂箱，郭軍，李萬里，王凱，旦真. 2024/08，ZL 202420071413.8
3.一種過氧化物酶體增值因子基因RkPEX11及其用途，張琦，馬紅俊，魏云林，陳媛，邱婧雯，2024/04，ZL 202310090676.3
4.一種乙酸滲透酶A基因RkAcpa及其應(yīng)用，張琦，范晶碟，熊超，魏云林，陳媛，邱婧雯，2024/04，ZL 202211334167.2
5.一種泛酸激酶基因RkPank及其應(yīng)用，張琦，熊超，魏云林，邱婧雯，陳媛，2024/04，ZL 202211333662.1
6.一種乙酰CoA合成酶基因RkACS2及其應(yīng)用，張琦，黃小嵐，楊曉霞，陳媛，邱婧雯，2024/04，ZL202310537742.7
7.一種NADH激酶基因RkNADHK1及其應(yīng)用，張琦，甘雨萱，陳汝藝，邱婧雯，陳媛，2024/03，ZL202310533180.9
8.馬乳酪蛋白小分子肽在制備二肽基肽酶Ⅳ抑制劑中的用途，伊日布斯，陳亞輝，高杰，陳子衡，成超，王嘉鑫，嚴(yán)金平，2024/02，ZL 202210004446.6
9.一種葡萄糖-6-磷酸脫氫酶基因RkZWF1及其應(yīng)用，張琦，陳汝藝，魏云林，邱婧雯，陳媛，2024/03，ZL 202211340770.1
10.一種紅冬孢酵母啟動(dòng)子及其應(yīng)用，張琦，郭銳，2023/09，ZL 202210174477.6
11.一種乙醛脫氫酶基因RKALDH及其應(yīng)用，張琦，倪金梅，郭彩娜，魏云林，季秀玲，2023/07，ZL 202210090376.0
12.一種馬乳源小分子肽及其應(yīng)用，伊日布斯，陳子衡，陳亞輝，成超，王嘉鑫，嚴(yán)金平，2023/07，ZL 202111481405.8
13.3-酮脂酰輔酶A硫解酶基因RKACAA1-2及其應(yīng)用，張琦，楊曉霞，陳功水，2023/04，ZL 202110895024.8
14.一種甲羥戊酸激酶基因RKMK及其應(yīng)用，張琦，郭彩娜，魏云林，2023/04，ZL 202210003665.2
15.3-酮脂酰-CoA硫解酶基因RkACAA1-1及其應(yīng)用，張琦，陳功水，魏云林，季秀玲，2023/03，ZL 202110895025.2
16.一種咖啡酸碳點(diǎn)在抗噬菌體中的應(yīng)用，魏云林，張春婷，秦堃豪，鄭曉丹，丁亞芳，季秀玲，張琦，2022/07，ZL 202110641050.8
17.乙酰CoA合成酶基因RKACS1及其應(yīng)用，張琦，鄒玲，陳波，2023/04，ZL 202110619574.7
18.一種植物乳桿菌的基因在葉酸生物生成中的應(yīng)用，柳陳堅(jiān)，趙志敏，李曉然，2023/04，ZL 202110251431.5
19.焦磷酸基因酶的用途，柳陳堅(jiān)，陳斯謙，李曉然，2023/03，ZL 202110246865.6
20.一株產(chǎn)蝦青素的紅冬孢酵母基因工程菌株，張琦，崔志城，肖興明，郭彩娜，魏云林，林連兵，季秀玲，2022/05，ZL 202010368747.8
21.一種酰基輔酶A氧化酶2基因RKACOX2及其應(yīng)用，張琦，劉韜，和美霞，魏云林，季秀玲，2022/03，ZL 202011322537.1
22.一種糞腸球菌噬菌體及其分離、純化、富集和應(yīng)用，魏云林，向盈盈，李文玉，宋飛，季秀玲，秦堃豪，張東芳，2022/02，ZL 201910333177.6
23.3-羥基-3-甲基戊二酸單酰輔酶A還原酶基因RKHMGR及其應(yīng)用，張琦，和美霞，魏云林，林連兵，季秀玲，2021/11，ZL 201911070771.7
24.HMG-CoA合成酶基因RKHMGCS及其應(yīng)用，張琦，陳波，魏云林，季秀玲，2021/10，ZL 201910240926.0
25.乙酰輔酶A乙酰轉(zhuǎn)移酶基因RKAcaT2及其應(yīng)用，張琦，張曉慶，魏云林，林連兵，季秀玲，2021/10，ZL 201910147204.0
26.一種蜂類毒理學(xué)和營養(yǎng)學(xué)實(shí)驗(yàn)用飼喂盒，郭軍，唐啟河，曹喆，陳奕霏，2021/09，ZL 202023235827.0
27.一種鑒定毛栓孔菌S0301中同核體菌株的方法，嚴(yán)金平，伊日布斯，楊恩，2021/08，ZL 201810175037.6
28.一個(gè)蘋果酸脫氫酶基因CIMDH1及其重組表達(dá)載體，張琦，季秀玲，魏云林，林連兵，2021/07，ZL 201810492054.2
29.鋅指轉(zhuǎn)錄因子基因RkMsn4的用途，張琦，季秀玲，魏云林，林連兵，2021/06，ZL 201810492044.9
30.一株糞腸球菌及其應(yīng)用，魏云林，向盈盈，季秀玲，宋飛，楊向紅，于鴻濱，周靜，秦堃豪，秦榕，2021/04，ZL 201910741574.7
31.一株基因工程菌乳酸乳球菌及其應(yīng)用，羅義勇，2021/03，ZL 201710944929.3
32.一種β-葡萄糖苷酶Ttbgl3及其應(yīng)用，嚴(yán)金平，張宇，曲媛，羅媛，李雪杰，楊旭磊，伊日布斯，2022/01，ZL 202011343650.8
（4）團(tuán)隊(duì)曾獲科研、教學(xué)獎(jiǎng)勵(lì)
云南省特殊生境噬菌體庫的建立及在難治性根尖周炎治療中的應(yīng)用，向盈盈,宋飛,季秀玲,魏云林,夏志剛,段開文，2024/04，云南省科技進(jìn)步獎(jiǎng)三等獎(jiǎng)
創(chuàng)新本科教學(xué)管理模式，科教融合構(gòu)建生命科學(xué)人才培養(yǎng)新高地,林連兵、夏雪山、李云軍、徐天瑞、宋玉竹、陳媛、李曉然、祝揚(yáng)揚(yáng)、高傳柱、向誠, 2023/03,云南省教學(xué)成果獎(jiǎng)二等獎(jiǎng)
